Cell chemical biologyHumansMyeloid-Lymphoid Leukemia ProteinHistone-Lysine N-MethyltransferaseAnimalsPeptides
Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression.
Ming Zhang, Meixia Chen, Peiyan Li, Jinrong Min
Published: 202510.1016/j.chembiol.2025.10.002
Abstract
WD40 repeat-containing protein 5 (WDR5) is a core component of the SET1/mixed lineage leukemia (MLL) complex that regulates gene expression via H3K4 methylation and plays a key role in maintaining oncogenic gene expression programs, particularly in M…
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