Cell chemical biologyHumansWnt Signaling PathwayUbiquitin-Protein LigasesLow Density Lipoprotein Receptor-Related Protein-6Animals
STT3A is essential for Wnt signaling and represents a target for cancers driven by RNF43 deficiency.
Zhengjin He, Shishuang Chen, Jinlong Suo, Kai Xia, Mingxian Liu, Jingchuan Ma, Yankai Chu, Chao Wang, Yueru Xie, Wei Jiang, Hui Du, Shiyang Chen, Zhilei Zhou, Man Li, Qing Wei
Published: 202510.1016/j.chembiol.2025.10.001
Abstract
Abnormalities in the Wnt pathway are major drivers of cancer. RNF43 loss-of-function mutations are frequently detected in aggressive cancers lacking targeted therapies, underscoring the need to uncover key regulators and targets of this pathway. Usin…
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