Cell chemical biologyAntimalarialsDrug ResistancePlasmodium falciparumHumansPiperidines
New twists in anti-malarial drug resistance.
José Cubillán-Marín, Tim W Gilberger
Published: 202510.1016/j.chembiol.2025.09.009
Abstract
In this issue of Cell Chemical Biology, Bopp et al.1 discover that malaria parasite resistance to halofuginone is mediated by mutations in PfApiAT2, an amino acid transporter, rather than halofuginone's target prolyl-tRNA synthetase. This rapid and d…
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