Cell chemical biologyHumansHypoxia-Inducible Factor 1alpha SubunitAnimalsMice
CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity.
Huiti Li, Ying Xu, Yimin Zheng, Zian Xue, Qingqing Li, Xinglong Jia, Lietao Weng, Lulu Jiang, Xiaoxue Ruan, Rong Zhang, Yue Yin, Liying Zhou, Fuyuan Li, He Huang, Jin Li
Published: 202510.1016/j.chembiol.2025.09.005
Abstract
HIF-1α transcriptional activity is enhanced through SUMOylation mediated by CBX4. Despite the recognized importance of the CBX4-HIF-1α axis, the molecular mechanisms governing its regulation remain largely unclear. In this study, phenotypic screening…
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