Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Placebo Rates in Metabolic Dysfunction-Associated Steatohepatitis Clinical Trials: A Systematic Review and Meta-Analysis.
Francisco Idalsoaga, Luis Antonio Díaz, Saleh Alghsoon, Bishoy Lawendy, Neha Sharma, Hailemichael Desalegn, Yuhong Yuan, My Ha, Jessica Le, John K MacDonald, Marco Arrese, Rohit Loomba, Vipul Jairath, Mohammad Qasim Khan, Juan Pablo Arab
Published: 202510.1016/j.cgh.2025.09.035
Abstract
BACKGROUND & AIMS: High placebo response rates complicate drug development in metabolic dysfunction-associated steatohepatitis (MASH) clinical trials. We performed a meta-analysis to quantify placebo response and assess influencing factors. METHODS:…
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