Cell reports
α-Ketoglutarate couples cellular metabolism to developmental growth via hydroxylation-dependent degradation of Yorkie.
Tao He, Yongchang Zeng, Jie Zhou, Yuqi Tian, Donggui Wang, Jingchao Ma, Jiyong Liu, Wenqi Wu, Chuanxian Wei, Renjie Jiao
Published: 202610.1016/j.celrep.2025.116922
Abstract
The evolutionarily conserved Hippo signaling pathway, essential for development and tissue homeostasis, is intimately linked to cellular metabolism. While cellular α-ketoglutarate (α-KG) levels fluctuate with metabolic state, the functional significa…
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