Cell reports
Targeting ZDHHC12-mediated PARP1 palmitoylation potentiates PARP inhibitor cytotoxicity.
Xining Zhang, Ye Liu, Xingming Liao, Min Wang, Jiao Liu, Yuemei Wen, Rongdiao Liu, Xiaolin Sang, Guohui Li, Pixu Liu, Huiying Chu, Hailing Cheng
Published: 202610.1016/j.celrep.2025.116910
Abstract
Poly(ADP-ribose) polymerase inhibitors (PARPi) elicit cytotoxicity by trapping PARP1 at DNA lesions, but clinical resistance remains a major challenge. Here, we identify reversible S-palmitoylation as a negative regulator of PARP1 chromatin engagemen…
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