Cell reports
Thyroid hormone augmentation accelerates hair cell maturation in human cochlear organoids.
Tsubasa Saeki, Yoshitomo Ueda, Isabel Aristizábal-Ramírez, Stephen T Moore, Rick F Nelson, Gregory I Frolenkov, Eri Hashino
Published: 202610.1016/j.celrep.2025.116898
Abstract
Human pluripotent stem cell-derived cochlear organoids are promising tools for studying human cochlear development and disease. However, the maturation of hair cells in these organoids is slow, requiring 200 days to express the mature outer hair cell…
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