Cell reports
Tumor-derived aminopeptidase N promotes early stages of brain metastatic colonization.
Leire Bejarano, Alberto Hernández-Barranco, Vincent Roh, Rui Santalla Méndez, Eleni Lamprou, Catia F Costa, Michelle Ballabio, Monika E Hegi, Nadine Fournier, Johanna A Joyce
Published: 202610.1016/j.celrep.2025.116895
Abstract
Metastasis is a highly inefficient process, with the vast majority of disseminated cancer cells failing to form secondary tumors. To establish brain metastases, cancer cells must traverse the blood-brain barrier and rapidly adapt to the specialized n…
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