Cell reports
Extracellular matrix stiffness drives post-mitotic nuclear pore complex assembly to promote neuroblastoma pathogenesis.
Guo-Zhu Sun, Chen Miao, Wen-Hao Tian, Jia-Long Cui, Zhong-Qian Liu, Yue Lou, Qing-Ping Yao, Kai Huang, Fan Lv, Ying-Xin Qi
Published: 202610.1016/j.celrep.2025.116858
Abstract
Nuclear pore complex (NPC) undergoes dynamic changes in physiology and pathology, yet its roles in neuroblastoma (NB) remain unclear. We demonstrated that rigid extracellular matrix (ECM) facilitated NPC-mediated nucleocytoplasmic transport in NB cel…
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