Cell reports
Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration and endolysosomal lipid accumulation in male PS19 mice.
G Travis Tabor, Alexandra Litvinchuk, Yun Chen, Austin Allison, Elizabeth W Sun, Bettina van Lengerich, Sonnet S Davis, Elizabeth West, Johannes C M Schlachetzki, Carisa Zeng, Hao Hu, Peter B Lin, Prabal Sharma, Xiaoying Chen, Samira Parhizkar
Published: 202610.1016/j.celrep.2025.116841
Abstract
Brain myeloid cells accumulate neutral lipids in multiple human neurodegenerative disorders and relevant mouse models. These lipids are often assumed to be contained in lipid droplets (LDs). While studies have been performed in cell culture and Droso…
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