Cell reports
Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10.
Jeanne Corriveau, Pascale Monot, Chantal Delisle, Marie-Anne Goyette, Camille Gasse, Yassine El Bakkouri, Trang Hoang, Jean-François Côté, Jean-Philippe Gratton
Published: 202510.1016/j.celrep.2025.116840
Abstract
Tumor angiogenesis is driven by pro-angiogenic factors and results in a disorganized tumor vasculature that limits effective perfusion and immune infiltration. The p21-activated kinase 2 (PAK2) regulates endothelial cell (EC) migration, an essential…
Preview only. Read the full abstract at the source