Cell reports
The FANCD2-FANCI heterodimer coordinates chromatin openness and cell cycle progression throughout DNA double-strand break repair.
Christine M Joyce, Julien Bacal, Soham P Chowdhury, Andrew N Brown, Amy K Wang, Carmen Cruz, Kameron Bains, Zachary N Rodriguez, Nathan J McCormick, Yaara Tzadikario, Katherine U Tavasoli, Brooke M Gardner, Chris D Richardson
Published: 202610.1016/j.celrep.2025.116830
Abstract
The FANCD2-FANCI heterodimer contributes to DNA repair at interstrand crosslinks and sites of replication stress. This complex has been physically and mechanistically linked to double-strand break (DSB) repair, but its role in that process remains un…
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