Cell reports
NNMT inhibition counteracts tubular senescence and fibrosis in early stages of chronic kidney disease.
Lucie Chanvillard, Hildo C Lantermans, Christopher Wall, Jonathan Thevenet, Loes M Butter, Loic Tauzin, Nike Claessen, Stefan Christen, James A Holzwarth, Sonia Karaz, Steve Lassueur, Giulia Lizzo, José Luis Sanchez-Garcia, Sylviane Métairon, Valentina Ferro
Published: 202610.1016/j.celrep.2025.116823
Abstract
Chronic kidney disease (CKD) is projected to become the fifth leading cause of mortality by 2040. Tubular senescence drives kidney fibrosis, but current treatments do not target senescent cells. Here, we identify nicotinamide-N-methyltransferase (NNM…
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