Cell reports
Tissue-specific restriction of transposon-derived regulatory elements safeguards cell-type identity.
Danica Milovanović, Julien Duc, Wayo Matsushima, Romain Hamelin, Evarist Planet, Sandra Offner, Olga Rosspopoff, Didier Trono
Published: 202610.1016/j.celrep.2025.116817
Abstract
Transposable elements (TEs) reshape mammalian cis-regulatory landscapes, but the mechanisms controlling their context-specific activity remain unclear. KRAB zinc finger proteins (KZFPs) typically repress TE-derived regulatory activity via TRIM28-medi…
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