Cell reports
Sequential RNA polymerase II activation drives human hematopoiesis.
Derek H Janssens, Christine A Codomo, Dominik J Otto, Lev Silberstein, Kami Ahmad, Steve Henikoff
Published: 202610.1016/j.celrep.2025.116802
Abstract
Promoter-proximal pausing of RNA polymerase II (Pol II) primes genes for rapid activation, yet how Pol II dynamics are temporally organized in adult stem cells to enable fast and flexible responses to environmental cues remain unknown. To address thi…
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