Cell reports
DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling.
Randall R Rainwater, Ana C Azevedo-Pouly, Zachary J Waldrip, Belle H Hicks, Nicholas A Callais, Brian Koss, Aaron J Storey, Lyle Burdine, Marie Schluterman Burdine
Published: 202610.1016/j.celrep.2025.116796
Abstract
Formation of the immune synapse (IS) following T cell antigen recognition includes recruitment of the linker for activation of T cells (LAT). Once at the IS, LAT tyrosines are phosphorylated, allowing it to serve as a scaffold for the formation of th…
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