Cell reports
Human liver cholangiocyte organoids capture the heterogeneity of in vivo liver ductal epithelium.
Javier Bregante, Flaminia Kaluthantrige Don, Fabian Rost, André Gohr, Germán Belenguer, Franziska Baenke, Dylan Liabeuf, Jessie Pöche, Clemens Schafmayer, Michaela Wilsch-Bräuninger, Sebastian Hinz, Kevin O' Holleran, Daniel E Stange, Meritxell Huch
Published: 202610.1016/j.celrep.2025.116786
Abstract
Human liver ductal epithelium is morphologically, functionally, and transcriptionally heterogeneous. Understanding the impact of this heterogeneity has been challenging due to the absence of systems that recapitulate this heterogeneity in vitro. Here…
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