Cell reports
IgG2c subclass dominance drives fatal lupus-like nephritis via FcγR and complement activation.
Yingying Luan, Pengfei Dai, Ying Wang, Jun Liu, Yanni Cai, Qing Min, Runyun Zhang, Ziying Hu, Zichao Wen, Lulu Dong, Weiguo Hu, Fubin Li, Leng-Siew Yeap, Jun Zou, Qian Shen
Published: 202510.1016/j.celrep.2025.116775
Abstract
Lupus nephritis (LN) is a leading cause of mortality in systemic lupus erythematosus. While the dominance of Fcγ receptor (FcγR)-activating IgG subclasses has been observed in both human and murine LN, whether this imbalance is causal or merely corre…
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