Cell reports
p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma.
Shirong Zhang, Mengjie Liu, Deli Tan, Kejia Lv, Wenyuan Li, Xubo Huang, Jia Hou, Yaru Yang, Chen Chen, Jinteng Feng, Wenjuan Wang, Lili Jiang, Min Jiao, Zhiping Ruan, Ying Zan
Published: 202510.1016/j.celrep.2025.116769
Abstract
Hyperactivation of the cell cycle in cancer cells suppresses antitumor immunity. The endogenous cyclin-dependent kinase inhibitor p57 is an important tumor suppressor and a potential therapeutic target for hepatocellular carcinoma (HCC). However, the…
Preview only. Read the full abstract at the source