Cell reports
The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain.
Lauryn A Higginson, Xingjun Wang, Kevin He, Maggie Torstrick, Minhoo Kim, H R Sagara Wijeratne, Avery M Runnebohm, Bérénice A Benayoun, Adam MacLean, Guillaume F Chanfreau, Derrick J Morton
Published: 202510.1016/j.celrep.2025.116729
Abstract
Intracellular ribonucleases (RNases) are essential for maintaining accurate RNA levels. Inherited mutations in genes encoding ubiquitous RNases are associated with human diseases, primarily affecting the nervous system. Recessive mutations in genes e…
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