Cell reports
Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway.
Hyun Min Ko, Bo Cao, Li Li, Hee-Won Park, Shelya X Zeng, Hua Lu
Published: 202510.1016/j.celrep.2025.116722
Abstract
Colorectal cancer (CRC) progression is driven by aberrant activation of oncogenic pathways, including AKT1, which requires mTORC2-mediated phosphorylation at Ser473. This study identifies PHLDB3 and Liprin-α1 as key regulators of RICTOR-dependent, mT…
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