Cell reports
STAT-independent functions of Janus kinases 1 and 2 are obligatory for the postnatal development of mammary epithelial ducts.
Rayane Dennaoui, Madison N Wicker, Carson Moen, Michaela Schlederer, Kerry Vistisen, Aleata A Triplett, Thomas Rülicke, Hallgeir Rui, Lukas Kenner, Emilio Casanova, Kay-Uwe Wagner
Published: 202510.1016/j.celrep.2025.116703
Abstract
Janus kinases 1 and 2 and STAT transcription factors are critical signaling nodes for numerous growth factors. In the mammary gland, JAK2 and STAT5a/b are essential for alveolar cell differentiation and lactation, but little is known about the cooper…
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