Cell reportsHumansAnimalsGTP-Binding Protein alpha SubunitsGsMice
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.
Vincent Quoc-Huy Trinh, Katherine E Ankenbauer, Sabrina M Torbit, Christopher P Taranto, Jiayue Liu, Maelle Batardiere, Bhoj Kumar, H Carlo Maurer, Frank Revetta, Zhengyi Chen, Angela R S Kruse, Audra M Judd, Celina Copeland, Jahg Wong, Olivia Ben-Levy
Published: 202510.1016/j.celrep.2025.116684
Abstract
Intraductal papillary mucinous neoplasms (IPMNs) are cystic lesions and bona fide precursors of pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid tumors. Although ∼90% of IPMNs are detected before PDAC forms, markers distinguishing…
Preview only. Read the full abstract at the source