Cell reportsHumansHistocompatibility Antigens Class IReceptorsFcAntiviral Agents
Structural hijacking of FcRn by human astrovirus spikes reveals conserved epitopes for broad-spectrum antivirals.
Sashank Agrawal, Monika Jain, Daniella Marinelli, So Yeon Cho, Bryan Briney, Ian A Wilson
Published: 202510.1016/j.celrep.2025.116679
Abstract
Human astroviruses (HAstVs) are a leading cause of pediatric gastroenteritis and emerging systemic infections; however, no targeted therapies exist. A critical barrier to intervention has been the lack of molecular insights into viral entry, particul…
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