Cell reportsAnimalsMicrogliaHumansOrganoidsBrain
Chimeric human organoid and mouse brain slice co-cultures to study microglial function.
Vasiliki Panagiotakopoulou, Marc Welzer, Olmo Ruiz Ormaechea, Diana Werner, Lena Erlebach, Anika Bühler, Ulrike Obermüller, Jonas J Neher, Mathias Jucker, Deborah Kronenberg-Versteeg
Published: 202510.1016/j.celrep.2025.116656
Abstract
Studying the dynamic role of microglia in brain development and neurodegenerative diseases requires models that closely resemble the human brain environment. While human induced pluripotent stem cell (iPSC)-derived organoids (hORGs) effectively repro…
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