Cell reportsHematopoietic Stem CellsAnimalsHumansExosomesCell Self Renewal
Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops.
Yinghao Pan, Hongna Zuo, Xianjin Yan, Jiali Li, Yuwen Li, Jin Li, You Wu, Liquan Hong, Mingwei Wang, Aiwei Wu, Zhenyu Ju, Yawei Gao, Hu Wang
Published: 202510.1016/j.celrep.2025.116650
Abstract
Pervasive transcription of the mammalian genome produces a vast repertoire of non-functional nascent transcripts, generating R loops and R-loop-induced DNA breaks. Such a coupling between continual transcription and a burst of R-loop formation, howev…
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