Cell reportsAnimalsMicrogliaAgingCerebellumTranscriptome
Spatial and single-cell transcriptomics reveal the reorganization of cerebellar microglia with aging.
Andy P Tsai, Douglas E Henze, Eduardo Ramirez Lopez, James Haberberger, Chuanpeng Dong, Nannan Lu, Micaiah Atkins, Emma K Costa, Amelia Farinas, Hamilton Se-Hwee Oh, Patricia Moran-Losada, Yann Le Guen, Alina Isakova, Stephen R Quake, Tony Wyss-Coray
Published: 202510.1016/j.celrep.2025.116624
Abstract
The cerebellum, essential for motor coordination and increasingly recognized for its role in cognition, is typically considered more resilient to aging and largely spared from hallmark Alzheimer's disease (AD) pathology. However, transcriptomic analy…
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