Cell reportsCarcinomaPancreatic DuctalAnimalsRibonucleoside Diphosphate ReductaseHistones
Dual inhibition of FACT and RRM2 suppresses the progression of pancreatic ductal adenocarcinoma driven by the oncohistone H2BG53D.
Tiantian Qin, Yi Ching Esther Wan, Shiman Hu, Jiaohua Chen, Xiaoxuan Zhu, Jiaqi Zhou, Yabin Chen, Xin Wang, Zongli Zheng, Landon Long Chan, Hoi Leong Xavier Wong, Haojie Jin, Junhong Han, Qing Li, Haiyun Gan
Published: 202510.1016/j.celrep.2025.116596
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with frequent genetic mutations. We previously reported the identification of the histone H2BG53D mutation and revealed that this mutation destabilizes nucleosomes and promotes cell mi…
Preview only. Read the full abstract at the source