Cell reportsAnimalsJanus Kinase 2BurnsAdipose TissueWhite
Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG.
Shixuan Zhuo, Zinan Wang, Lanzexin Yang, Yixuan Yuan, Dahai Hu, Yan Chen
Published: 202510.1016/j.celrep.2025.116577
Abstract
Browning of white adipose tissue (WAT) contributes to the sustained hypermetabolism observed in patients with burns. How glycogen metabolism in WAT is linked to burn-induced hypermetabolism remains unknown. We discover that burn-induced UCP1 expressi…
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