Cell reportsMaleCyclin-Dependent Kinase 4HumansCyclin-Dependent Kinase 6Prostatic Neoplasms
Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer.
Xurui Li, Zhenghui Sun, Ruijiang Zeng, Ruiling Liu, Pingxia Lin, Zhuo Xing, Xin Jin, Tiejun Yang
Published: 202510.1016/j.celrep.2025.116530
Abstract
A high-fat diet (HFD) promotes tumor progression and therapeutic resistance, but its mechanistic role in prostate cancer (PCa) remains unclear. In this study, we show that an HFD not only accelerates PCa progression but also significantly reduces sen…
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