Cell reportsAnimalsMiceHair CellsAuditoryReceptors
The force-sensing GPCR LPHN2 is indispensable for normal auditory function.
Shu-Hua Zhou, Ming-Wei Wang, Zhi-Chen Song, Zhao Yang, Kong-Kai Zhu, Xin Wen, Qi-Yue Zhang, Ying Guan, Jia-Rui Gao, Xiao-Hui Wang, Ya-Qi Wang, Wen-Wen Liu, Lei Xu, Wei Xiong, Ren-Jie Chai
Published: 202510.1016/j.celrep.2025.116519
Abstract
The conversion of force sensation into electrical signals via mechano-electrical transduction (MET) is considered the key step in auditory perception. Here, we find that the G-protein-coupled receptor (GPCR) LPHN2/ADGRL2 is expressed at the tips of s…
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