Cell reportsAnimalsGoblet CellsHomeostasisMiceHumans
Goblet cell-expressed microprotein FXYD3 determines gut homeostasis by maintaining mucus barrier integrity.
Wenjuan Yang, Yue Xue, Peishuo Zhu, Zhinong Jiang, Rukun He, Hengrui Tian, Tao Wang, Peng Xiao, Wenwen Lian, Qian Cao, Yunn-Hwen Gan, Lihua Lai, Qingqing Wang
Published: 202510.1016/j.celrep.2025.116502
Abstract
The intestinal mucus layer produced by goblet cells is a critical component of innate immunity. The key host factors and regulatory mechanisms controlling goblet cell function in mucus layer formation remain poorly understood. This study identifies a…
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