Cell reportsAnimalsCorticotropin-Releasing HormoneOligodendrogliaCell DifferentiationReceptors
Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development.
Clemens Ries, Tibor Stark, Benoit Boulat, Torben Ruhwedel, Jan Philipp Delling, Antonio Miralles Infante, Julia T von Poblotzki, Alessandro Ulivi, Iven-Alex von Mücke-Heim, Simon Chang, Kenji Sakimura, Keiichi Itoi, Dennis B Nestvogel, Alessio Attardo, Michael Czisch
Published: 202510.1016/j.celrep.2025.116474
Abstract
The role of neuropeptides and their receptors in oligodendrocyte (OL) progenitor cells (OPCs) has been largely overlooked so far. Here, we describe a new subpopulation of corticotropin-releasing hormone (CRH)-expressing OPCs. Brain injury rapidly ind…
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