Cell reportsFluorouracilCitrobacter freundiiHumansDrug ResistanceNeoplasm
PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer.
Weiben Xu, Ying Zhou, Haiying Ding, Mengqian Ye, Shujing Li, Linwei Xu, Xiangyu Jin, Zhajun Zhan, Lulu Song, Yuhua Zhang, Canming Wang, Zhengqin Zhu, Liefeng Ma, Libin Pan, Luo Fang
Published: 202510.1016/j.celrep.2025.116473
Abstract
Pancreatic cancer is highly malignant, and while fluoropyrimidines (5-fluorouracil [5-FU] and capecitabine) are critical first-line treatments for metastatic cases, drug resistance remains a major challenge. In this study, we identified an associatio…
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