Cell reportsAnimalsZebrafishFibroblastsInflammationSpinal Cord Regeneration
Biphasic inflammation control by fibroblasts enables spinal cord regeneration in zebrafish.
Nora John, Thomas Fleming, Julia Kolb, Olga Lyraki, Sebastián Vásquez-Sepúlveda, Asha Parmar, Kyoohyun Kim, Maria Tarczewska, Pooja Gupta, Kanwarpal Singh, Federico Marini, Sumeet Pal Singh, Vasiliki Tsata, Sven Falk, Kristian Franze
Published: 202510.1016/j.celrep.2025.116469
Abstract
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). Here, we show that in zebrafish, the interplay between fibroblasts and immune cells is required for regene…
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