Cell reportsHumansLung NeoplasmsCarcinomaNon-Small-Cell LungMutation
Deciphering genomic evolution of metastatic organotropism with 535 paired primary lung cancers and metastases.
Duo Xie, Wen-Fang Tang, Tao Jiang, Hao Duan, Shanlan Mo, Hao Zhang, Xiangwei Zhai, Qingda Tian, Zan Li, Yi Liang, Wei-Zhao Huang, Hai-Ming Jiang, Leo Tsz On Lee, Chao Zhang, Weiwei Zhai
Published: 202510.1016/j.celrep.2025.116449
Abstract
Metastasis is the leading cause of death in lung cancer patients, yet our understanding of its genomic determinants and evolution remains limited. Here, we analyzed whole-exome sequencing data from 535 paired primary and metastatic tumors from 223 no…
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