Cell reportsSerotoninHumansAnimalsGastrointestinal MicrobiomeColon
Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation.
Chiara H Moretti, Estelle Grasset, Jiaying Zhu, Gaohua Yang, Louise E Olofsson, Muhammad Tanweer Khan, Per-Olof Bergh, Jee-Hwan Oh, Annika Lundqvist, Tom van Gils, Manuela Krämer, Lisa M Olsson, Piyush Patel, Matthias Mitteregger, Daysi Espinola Monges
Published: 202510.1016/j.celrep.2025.116434
Abstract
The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility. Functional bowel disorders, including irritable bowel syndrome, are asso…
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