Cell reportsHumansPoly (ADP-Ribose) Polymerase-1Pancreatic NeoplasmsAnimalsMice
Targeting the UFL1-PARP1 axis amplifies anti-tumor immunity.
Wenjing Song, Chuan He, Xixin Xing, Gaoshan Xu, Yingmeng Yao, Haiou Li, Yishuang Sun, Wenjun Xiong, Yang Shi, Dilinigeer Tayier, Kechun Yu, Xue Zhang, Zuosong Xie, Yufeng Yuan, Zhiyong Yang
Published: 202510.1016/j.celrep.2025.116433
Abstract
Cancer immunotherapies are widely used to treat various cancers but are largely ineffective against pancreatic ductal adenocarcinoma (PDAC), with the underlying mechanisms poorly understood. UFMylation, a ubiquitin-like modification, regulates divers…
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