Cell reportsInosineAstrocytesAnimalsEquilibrative-Nucleoside Transporter 2Mice
Equilibrative nucleoside transporter 2 modulates inosine catabolism to influence astrocyte metabolism and reactivity.
Ya-Gin Chang, Hsin-Chuan Lin, Ching-Pang Chang, Hsing-Lin Lai, Hui-Mei Chen, Haoning Huang, Pei-Rong Chang, Ching-Wen Wu, Chin-Jui Ho, Ting Chu, Chun-Jung Lin, Yijuang Chern
Published: 202510.1016/j.celrep.2025.116420
Abstract
Astrocytes display diverse reactive patterns in response to different stimuli, a phenomenon known as the heterogeneity of astrocyte reactivity. Although the mechanisms underlying these reactive states remain debated, energy metabolism is believed to…
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