Cell reportsHumansPulmonary DiseaseChronic ObstructiveBacteriophagesMicrobiota
Bacteriophage diversity declines with COPD severity in the respiratory microbiome.
Ryan A Cook, Alise J Ponsero, Andrea Telatin, Yuqiong Yang, Zhenyu Liang, Fengyan Wang, Rongchang Chen, Zhang Wang, Evelien M Adriaenssens, Martha R J Clokie, Andrew D Millard, Christopher E Brightling
Published: 202510.1016/j.celrep.2025.116413
Abstract
Chronic obstructive pulmonary disease (COPD) severity correlates with airway microbial dysbiosis, yet bacteriophage roles remain unexplored. We characterized the lung DNA virome by re-analyzing 135 sputum metagenomes from 99 COPD patients and 36 heal…
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