Cell reportsHumansTriple Negative Breast NeoplasmsPolycomb Repressive Complex 2Cell MovementCell Line
PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells.
Nina Pelzer, Teodora Lukic, Wanwan Ge, Nina Schnabel, Peter Teufel, Monilola A Olayioye, Zeynab Najafova, Cristiana Lungu
Published: 202510.1016/j.celrep.2025.116391
Abstract
Polycomb repressive complex 2 (PRC2) is a key regulator of transcriptional repression and chromatin organization, essential in development and disease. While its enzymatic activity is well characterized, the factors governing PRC2 subnuclear organiza…
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