Cell reportsHumansTelomeraseColorectal NeoplasmsHereditary NonpolyposisPromoter Regions
Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer.
Jussi Nikkola, Lauri Ryyppö, Juuso Vuorinen, Lauri Moilanen, Maarit Ahtiainen, Kirsi Pylvänäinen, Hanna Selin, Tuomo Virtanen, Matti Nykter, Thea Veitonmäki, Jukka-Pekka Mecklin, Toni T Seppälä, Matti Annala
Published: 202510.1016/j.celrep.2025.116388
Abstract
Lynch syndrome (LS) is a hereditary condition characterized by defective DNA mismatch repair and a high incidence of several cancers. In this study, we investigate the somatic landscape of LS-associated urothelial cancer (LS-UC) by analyzing 41 tumor…
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