Cell reportsAnimalsOtx Transcription FactorsPluripotent Stem CellsHumansMice
LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs.
Linhui Wu, Peng Su, Delong Li, Kai Zhou, Wenting Song, Juanjuan Shi, Qi Wang, Qianfu Huang, Siyi Hu, Xia Zhang, Xin Liu, Jilong Zhou, Yi-Liang Miao
Published: 202510.1016/j.celrep.2025.116385
Abstract
The molecular characteristics of expanded pluripotent stem cells (EPSCs) remain debated. Human EPSCs (hEPSCs) resemble embryos at the 8-cell to morula stage, while mouse EPSCs (mEPSCs) resemble post-implantation epiblasts. This study examines the dev…
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