Cell reportsAnimalsCell DifferentiationTranscription FactorsT Follicular Helper CellsMice
Contextual regulation of T follicular helper cell expansion and differentiation into T regulatory type 1 cells by multiple transcription factors.
Josep Garnica, Jun Yamanouchi, Shari Thiessen, Joel Moro, Enric Canut, Mireia Palou, Debajyoti Mondal, Pau Serra, Pere Santamaria
Published: 202510.1016/j.celrep.2025.116381
Abstract
Differentiation of naive T cells into T helper (TH), including T follicular helper (TFH), cell subsets is regulated by subset-specific transcription factors (TFs). We examine the role of 20 TFs binding to motifs enriched in open chromatin regions of…
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