Cell reportsNeural CrestAnimalsSarcomaEwingMesoderm
Origin of Ewing sarcoma by embryonic reprogramming of neural crest to mesoderm.
Elena Vasileva, Claire Arata, Yongfeng Luo, Ruben Burgos, J Gage Crump, James F Amatruda
Published: 202510.1016/j.celrep.2025.116376
Abstract
Ewing sarcoma is a malignant small round blue cell tumor caused by chromosomal translocations that generate aberrant fusion oncogenes, most frequently EWSR1::FLI1. The cell of origin and mechanisms of EWSR1::FLI1-driven transformation have remained u…
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