Cell reportsAnimalsUrethraMiceNeurogenic InflammationSubstance P
Tuft cells trigger neurogenic inflammation in the urethra.
Patricia Schmidt, Uwe Pfeil, Mahmoud Lafee, Swantje Petersen, Alexander Perniss, Maryam Keshavarz, Debajyoti Das, Amanda Wyatt, Ulrich Boehm, Burkhard Schütz, Wolfgang Kummer, Klaus Deckmann
Published: 202510.1016/j.celrep.2025.116370
Abstract
Cholinergic urethral tuft cells (UTCs) are regarded as sentinels of microbial products in the urogenital tract, initiating reflex micturition as a protective mechanism. We here hypothesize that acetylcholine released by stimulated UTC leads to neurog…
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