Cellular signalling
AKR1C3 promotes aerobic glycolysis in hepatic stellate cells via the AKT/mTOR pathway to induce liver fibrosis.
Tao Ran, Qing-Xiu Zhang, Hua-Yue Wu, Shu Feng, Lu Han, Yuan Qin, Guo-Yuan Lin, Ya Zhang, Shi-Liang Li, Ji-Yu Chen, Yu-Mei Zhou, Shi-Qian Cai, Xue-Ke Zhao
Published: 202610.1016/j.cellsig.2026.112369
Abstract
Liver fibrosis (LF) represents a common wound-healing response to various forms of liver injury. Activation of hepatic stellate cells (HSCs) is a central event in this process. Aerobic glycolysis plays a critical role in the sustained activation of H…
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