Cellular signalling
Annexin A5 ameliorates immune-mediated liver injury by regulating ferritinophagy-ferroptosis in M2 macrophages via the NRF2/ERK pathway.
Junfeng Li, Zibing Qian, Zheyu Li, Xiaorong Mao, Aipin Tian, Xuebin Peng, Zhongxia Yang, Kai Yang
Published: 202610.1016/j.cellsig.2026.112366
Abstract
BACKGROUND & AIM: M2 macrophages are key drivers of immune-mediated liver injury. The aim of this study was to investigate the mechanisms by which Annexin A5 regulates ferroptosis in M2 macrophages and its protective effect against immune liver injur…
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