Cellular signallingIsoflavonesAnimalsReperfusion InjuryProto-Oncogene Proteins c-aktPhosphatidylinositol 3-Kinases
Puerarin protects against renal ischemia-reperfusion injury by restoring mitochondrial function and modulating the PI3K/AKT/NF-k B pathway and suppressing inflammatory responses.
Kangyu Wang, Changhong Xu, Hao Wang, Yalong Zhang, Zijian Zhang, Rui Yan, Li Wang, Jianwei Yang, Jiangwei Man, Li Yang
Published: 202610.1016/j.cellsig.2025.112350
Abstract
BACKGROUND: Renal ischemia-reperfusion injury (RIRI) is a major cause of perioperative acute kidney injury and a driver of chronic kidney disease, in which mitochondrial dysfunction and inflammatory activation create a vicious cycle of oxidative stre…
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